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General Nutrition: Using the Library's Databases

Articles from PubMed

Happy Gut

On the following pages you will find books and websites that will provide information on nutrition and diet. You will be asked to differentiate between primary articles and review, or lay, articles.   Primary articles are those that describe original research done by the author as described on this page.  Review or lay articles are recaps of other scientists' research.  

Many articles can be retrieved "full text" or entirely from an electronic sources.  Others may have to be ordered through Interlibrary Loan  and  will come directly to your Mount's email.

If the article you want does not come back from Interlibrary Loan as filled, please come see any research librarian and we will get it for you.

On this page you find databases that we provide for your use.  Below you will find an article excerpt from an article found in Pubmed.  The whole article is available at:    

http://dx.doi.org/10.1016/j.cell.2013.11.024


 

 
Referred to by
 

Highlights

The MIA model recapitulates GI comorbidities linked to a subset of ASD individuals

Targeting the microbiota treats specific GI and behavioral symptoms

Gut microbes regulate metabolites that alter behavior in animals
Microbiota may contribute to the pathophysiology of neurodevelopmental disorders

 


Summary

Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites. Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior. Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.

 

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